PCR Detection of C. difficile in 43 Minutes

Xpert® C. difficile BT

 
 

Clostridioides difficile (C. difficile) is amongst the biggest causes of infectious diarrhoea in hospitalised patients, and one of the most reported hospital-acquired infections (HAIs).1 C. difficile associated with increased length of hospital stay and high morbidity, mortality, and costs.2 

 

Rapid and accurate diagnosis of C. difficile are critical for expediting appropriate therapy and infection prevention measures and help improve patient outcomes and limit onward transmission.3

 

 

Who Should be Tested?

Diagnostic testing should typically be performed in patients with significant clinical indicators, most notably diarrhoea (Bristol Stool Chart types 5–7 in ≤ 24 hours) who are more at risk for C. difficile, in particular those with:4 

  • Recent exposure to antibiotics
  • Older age (>65 years)
  • Recent hospitalisation
  • Chronic underlying illness
 

Why Test with Fast PCR?

Fast and accurate PCR diagnostics with Cepheid’s GeneXpert® system and Xpert® C. difficile BT test provide standardised, on-demand, and actionable results in 43 minutes, streamlining complex and timely algorithmic or batch-based methodologies and supporting improved patient outcomes.3

 

Toxin EIA (enzyme immunoassay) and GDH tests are not sensitive/specific enough for standalone use.3 With the emergence of more virulent strains (e.g., ribotype 955) rapid molecular detection and call-out of the epidemic 027 strain has also become even more important.

 

Xpert C. difficile BT

Detection of C. difficile infection with an independent call-out for binary toxin and differentiation of the 027 strain in 43 minutes.


Impact:

  • Reduced empiric therapy3

  • Improved use of isolation beds5

  • Reduced hospital-acquired C. difficile5

GeneXpert® Systems

Our GeneXpert® family of systems have set a new standard in workflow flexibility, 24/7 accuracy, and user-friendly design.

 

Our engaging platform delivers:

  • On-demand and random-access walkway testing
  • Unique scalability and flexible design from 2-80 modules
  • Simplified workflow
  • Easy to maintain
  • Full connectivity

 

>30 CE-IVD Tests, One GeneXpert System for Consolidated HAI PCR Testing

COVID-19, Flu & RSV

Results in 36 minutes

Carbapenem-resistant Bacteria

Results in 50 minutes

C. difficile

Results in 43 minutes

Group B Streptoccoccus

Results in 56 minutes

MRSA

Results in 47 minutes^

TB & Resistance

Results in <90 minutes

Norovirus

Results in 60 minutes#

Vancomycin-resistant Bacteria

Results in 48 minutes

 

Choose Cepheid as your Trusted Diagnostics NHS Partner Today

Over the last 28 years, Cepheid has partnered with many hospitals, clinics, and laboratories around the world with more than 40,000 systems installed and millions of tests performed, including ~2 million PCR tests delivered to NHS hospitals each year6, changing the lives of millions of patients.

 

With our solutions, your healthcare organisation can potentially reduce costs, streamline operations, and maximise productivity while prioritising patient health.

 

Download C. difficile Infographic

Speak to our experts about your stewardship and outbreak prevention plan

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CE-IVD. In Vitro Diagnostic Medical Device. May not be available in all countries.

^ For positive MRSA results with early assay termination. Otherwise, full runtime is 70 minutes.
# For positive Norovirus results with early assay termination. Otherwise, full runtime is 90 minutes.

1. Guery B, et al. Clostridioides difficile: diagnosis and treatments. BMJ. 2019 Aug;20(366):4609.

2. Tresman R & Goldenberg S. Healthcare resource use and attributable cost of Clostridium difficile infection: a micro-costing analysis comparing first and recurrent episodes. JAntimicrob Chemother. 2018 Oct;73(10):2851-2855.

3. Peppard W, et al. Implementation of polymerase chain reaction to rule out C. difficile infection is associated with reduced empiric antibiotic duration of therapy. HospPharm. 2014 Jul;49(7):639-43.

4. Kociolek, L. K., Gerding, et. al. Strategies to prevent clostridioides difficile infections in acute-care hospitals: 2022 update. Infection Control & Hospital Epidemiology, 44(4),527–549.

5. Casari E, et al. Reducing rates of C. difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resist Infect Control. 2018 Mar;7(40).

6. 2023 Internal data analysis actual 1.9.

About Cepheid

Cepheid is dedicated to improving healthcare by pioneering molecular diagnostics that combine speed, accuracy, and flexibility. The company's GeneXpert® systems and Xpert® tests automate highly complex and time-consuming manual procedures, providing A Better Way for institutions of any size to perform world-class PCR testing. Cepheid's broad test portfolio spans respiratory infections, blood virology, women's and sexual health, TB and emerging infectious diseases, healthcare-associated infectious diseases, oncology and human genetics. The company's solutions deliver actionable results where they are needed most from central laboratories and hospitals to near patient settings.

For more information, visit www.cepheid.com

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